coating-developed-by-jncasr-may-prevent-transmission-of-infection-summary

Context: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) has developed a one-step curable anti-microbial coating which, when coated on different surfaces such as textile, plastic and so on could kill a range of virus types including COVID 19.

About the research:

  • The recent outbreak of SARS-CoV-2 has created an unprecedented stir in global public health. Like influenza, Coronavirus is also an enveloped virus
  • JNCASR has developed a one-step curable anti-microbial coating which, when coated on different surfaces such as textile, plastic and so on could kill a range of virus types including COVID 19.
  • This covalent coating  has been found to completely kill influenza virus as well as resistant pathogenic bacteria and fungi, including methicillin-resistant Staphylococcus aureus and fluconazole-resistant C. albicans spp.
  • In brief, for coating on cotton, the sheets were dipped in a water solution of the compounds whereas, for other cases, ethanolic substrates were drop-casted on them followed by UV irradiation. (In chemistry, a substrate can refer to a surface on which other chemical reactions are performed)
  • After coating, the surfaces were evaluated for their antibacterial, antifungal, and antiviral activity.
  • Upon the formation of the coating, it has been shown to permeabilize the membranes of pathogens (i.e. bacteria) leading to their inactivation.

Enveloped Virus

  • A virus that has an outer wrapping or envelope. This envelope comes from the infected cell, or host, in a process called "budding off." 
  • During the budding process, newly formed virus particles become "enveloped" or wrapped in an outer coat that is made from a small piece of the cell's plasma membrane. 
  • The envelope may play a role in helping a virus survive and infect other cells.

Benefits:

  • Can help prevent contamination: 
    • Till date(to the best of our knowledge) there is no covalent coating strategy which can kill all viruses, bacteria and fungi. 
    • Therefore it is anticipated that the coating may inactivate SARS-CoV-2 upon contact and can help prevent contamination if coated on various surfaces.
  • The coating can be fabricated on a variety of surfaces, and its ease and robustness eliminate the necessity of skilled personnel for procurement of the coating.
  • Ability to cross-link: The molecules developed have an ability to chemically cross-link with different surfaces upon UV irradiation. 

Considering the current coronavirus outbreak, if shown to be active, the molecule can be synthesized in large scale through a CRO (Contract Research Organization) and can be coated on various personal protective tools such as masks, gloves, gowns, etc. in collaboration with the private organizations. 

Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) 

  • It is an autonomous institution under(and funded by) the Department of Science and Technology,  Government of India and is a deemed university.
  • It is a multidisciplinary research institute situated in Bangalore, India. It is relatively young yet well-known around the Globe.
  • It’s mandate is to pursue and promote world-class research and training at the frontiers of Science and Engineering covering broad areas ranging from Materials to Genetics.
  • It provides a vibrant academic ambience hosting more than 300 Researchers.

Source: https://pib.gov.in/PressReleseDetail.aspx?PRID=1609970

Image source: DST